• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >The validation of a three-stage screening methodology for detecting active convulsive epilepsy in population-based studies in health and demographic surveillance systems.
【2h】

The validation of a three-stage screening methodology for detecting active convulsive epilepsy in population-based studies in health and demographic surveillance systems.

机译：在健康和人口监测系统的基于人口的研究中，用于检测活动性惊厥性癫痫的三阶段筛查方法的验证。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

UNLABELLED: BACKGROUND: There are few studies on the epidemiology of epilepsy in large populations in Low and Middle Income Countries (LMIC). Most studies in these regions use two-stage population-based screening surveys, which are time-consuming and costly to implement in large populations required to generate accurate estimates. We examined the sensitivity and specificity of a three-stage cross-sectional screening methodology in detecting active convulsive epilepsy (ACE), which can be embedded within on-going census of demographic surveillance systems.We validated a three-stage cross-sectional screening methodology on a randomly selected sample of participants of a three-stage prevalence survey of epilepsy. Diagnosis of ACE by an experienced clinician was used as 'gold standard'. We further compared the expenditure of this method with the standard two-stage methodology. RESULTS: We screened 4442 subjects in the validation and identified 35 cases of ACE. Of these, 18 were identified as false negatives, most of whom (15/18) were missed in the first stage and a few (3/18) in the second stage of the three-stage screening. Overall, this methodology had a sensitivity of 48.6% and a specificity of 100%. It was 37% cheaper than a two-stage survey. CONCLUSION: This was the first study to evaluate the performance of a multi-stage screening methodology used to detect epilepsy in demographic surveillance sites. This method had poor sensitivity attributed mainly to stigma-related non-response in the first stage. This method needs to take into consideration the poor sensitivity and the savings in expenditure and time as well as validation in target populations. Our findings suggest the need for continued efforts to develop and improve case-ascertainment methods in population-based epidemiological studies of epilepsy in LMIC.
机译：背景：在中低收入国家（LMIC），大量人群的癫痫流行病学研究很少。这些地区的大多数研究都使用基于人口的两阶段筛查调查，这种调查既耗时又成本高昂，需要大量人口才能生成准确的估算值。我们检查了三阶段横断面筛查方法在检测活动性惊厥性癫痫（ACE）中的敏感性和特异性，该方法可以嵌入正在进行的人口普查系统中。我们验证了三阶段横断面筛查方法对癫痫病的三阶段患病率调查参与者的随机选择样本。由经验丰富的临床医生对ACE的诊断被用作“黄金标准”。我们进一步将该方法的支出与标准的两阶段方法进行了比较。结果：我们筛选了4442名受试者，确定了35例ACE患者。其中，有18个被鉴定为假阴性，其中大部分（15/18）在三阶段筛选的第一阶段被漏失，而少数（3/18）在三阶段筛选的第二阶段被漏失。总体而言，该方法的灵敏度为48.6％，特异性为100％。比两阶段调查便宜37％。结论：这是第一项评估多阶段筛查方法性能的研究，该方法用于检测人口统计学监测部位的癫痫。该方法灵敏度低，主要是由于在第一阶段与柱头相关的无反应。这种方法需要考虑到敏感性差，节省开支和时间以及在目标人群中进行验证的情况。我们的发现表明，在LMIC癫痫的人群基础流行病学研究中，需要继续努力发展和改善病例确定方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号